Civilization (the game)
Civilization is a strategy game that originated as a board game for multiple players, that become very popular as a computer game played by one person against computer opponents. Because it is a strategy game it has been used to teach strategy, but has also been useful for demonstrating economics, politics, armed conflict, cultural development, and environmental impacts of growth and technology.

A Norwegian example
A critique of the educational aspects
Civilization V is coming to North American high schools next year - Verge